No molecule in a living organism exists in a vacuum. Indeed, each interacts with thousands of other molecules, and the functions associated with each gene product are influenced by surrounding proteins, metabolites, and other molecules. The existence of complex pathways governing phenotypes poses a substantial challenge in efforts to diagnose complex diseases, unravel their causes, and to develop effective therapeutics.
In our lab, we use systems biology approaches to make sense of these complex pathways to develop network-based diagnostics for childhood disorders (Autran, Gut, 2017; Courchesne, Mol Psychiatry, 2018; Gazestani, bioRxiv 2018) and to understand the regulation and activity of complex pathways, such as metabolism (Hefzi, Cell Systems, 2016; Richelle, PLoS Comp Bio, 2019; Brunk, PNAS 2018), protein synthesis/secretion (Gutierrez, bioRxiv, 2018), and glycosylation (Spahn, Met Eng, 2016). Insights are also used to guide synthetic biology efforts to engineer mammalian cells for biotherapeutic purposes (Richelle, Curr Opin in Sys Bio, 2017; Kuo, Curr Opin in Biotech, 2018; Hefzi, submitted; Chiang, bioRxiv, 2018). Click on the links below for details on current Research Projects, Resources, and Open Positions.